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KMID : 0353420180420040198
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Oral Biology Research
2018 Volume.42 No. 4 p.198 ~ p.207
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A study of bone regeneration effect according to the two different graft bone materials in the cranial defects of rabbits
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Song Hyun-Jong
Kim Hyun-Woo
Min Gwi-Hyeon
Lee Won-Pyo
Yu Sang-Joun
Kim Byung-Ock
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Abstract
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Guided tissue regeneration (GBR) has been used to promote new bone formation in alveolar bone reconstruction at defective bonesites following tooth loss. Bone grafts used in GBR can be categorized into autogenous, xenogenous, and synthetic bones, and humanallografts depending on the origin. The purpose of this study was to compare the rates of bone regeneration using two different bonegrafts in the cranial defects of rabbits. Ten New Zealand rabbits were used in this study. Four defects were created in each surgical site. Each defect was filled as follows: with nothing, using a 50% xenograft and 50% human freeze-dried bone allograft (FDBA) dependingon the volume rate, human FDBA alone, and xenograft alone. After 4 to 8 weeks of healing, histological and histomorphometricanalyses were carried out. At 4 weeks, new bone formation occurred as follows: 18.3% in the control group, 6.5% in group I, 8.8% ingroup II, and 4.2% in group III. At 8 weeks, the new bone formation was 14.9% in the control group, 36.7% in group I, 39.2% in groupII, and 16.8% in group III. The results of this study suggest that the higher the proportion of human FDBA in GBR, the greater was theamount of clinically useful new bone generated. The results confirm the need for adequate healing period to ensure successful GBRwith bone grafting.
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KEYWORD
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Allografts, Bone substitutes, Guided tissue regeneration, Heterografts
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